You may warm the solution in a microwave.
The easy-squeeze bottle system allows you to deliver saline solution with sufficient pressure to clean your nasal passages thoroughly, while maintaining your head in a comfortable position. We recommend that you warm it in increments of five seconds. NeilMed SinuFLO ReadyRinse is a premixed solution that lets you enjoy a natural, soothing saline nasal wash anywhere in the world, without having to measure ingredients or find purified water. Keeping your mouth open without holding your breath, place cap snugly against your nasal passage and SQUEEZE BOTTLE GENTLY until the solution starts draining from the OPPOSITE nasal passage or from your mouth.